Knee osteoarthritis is a prevalent degenerative joint disorder that significantly impairs mobility and quality of life. Intra-articular injections, such as those containing corticosteroids and hyaluronic acid, are commonly used for symptom relief, often in conjunction with physical therapy. However, comparative data on their combined efficacy in clinical practice remain limited. This study aimed to evaluate and compare the clinical effectiveness of intra-articular corticosteroids and hyaluronic acid, each combined with physiotherapy, in reducing pain and improving range of motion in patients with knee osteoarthritis. A total of 60 Libyan patients with knee osteoarthritis treated at Mitiga Military Hospital were randomly assigned to three groups (n=20 each): Group A: received corticosteroid injections plus physiotherapy, Group B: received hyaluronic acid injections plus physiotherapy, and Group C: received physiotherapy alone. Pain intensity was assessed using the visual analog scale, and joint function was measured using active and passive range of motion assessments. Evaluations were conducted at baseline and four weeks post-treatment. Data were analyzed using a paired t-test and ANOVA. All groups demonstrated significant reductions in visual analog scale scores and improvements in range of motion post-treatment (p<0.001). Group A exhibited the greatest pain reduction (6.15±1.42 to 2.00±1.17), while Group B showed superior improvement in range of motion (passive: 101.20°±11.45° to 122.45°±8.69°). Group C demonstrated moderate but statistically significant improvement in both parameters. Corticosteroid and hyaluronic acid injections, when combined with physiotherapy, significantly improve pain and joint function in knee osteoarthritis patients. Corticosteroids may offer faster pain relief, while hyaluronic acid appears more effective in enhancing joint mobility. These findings support the use of tailored treatment approaches based on individual patient needs and therapeutic goals.