Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. The study aimed to determine the variables that would predict the vaccination rollouts. The objective of this study was to determine the acceptance of the COVID-19 vaccine among the general adult population in Libya and assess its determinants. Specifically, it aims to answer the following questions: What are the variables that would predict the vaccination rollouts, in terms of knowledge about the vaccine, exposure to coronavirus 2? What is the respondent's level of acceptance of COVID-19 vaccination? Is there a significant relationship between the predictors of vaccination turnouts and the level of acceptance of COVID-19 vaccination? The findings that the researcher was able to extract from the study were: The frequency and percentage of the Knowledge as a predictor of vaccination turnouts is 94.1% for YES and 5.8% for NO. In terms of exposure to the coronavirus, those who tested positive for COVID-19 yielded a result of 29.4%, and those who tested negative with 70.5%. Detailed analysis of the results reveals that the level of acceptance of respondents to COVID-19 vaccination is 52.9% for YES, they will avail, and 47.0% for NO, they would not want to avail. Both determinants, the knowledge and exposure to coronavirus, yielded a positive, strong relationship with the level of acceptance of COVID-19 vaccination.